- Médecine
- Human Reproduction
Labo de recherche en reproduction humaine
Welcome
Welcome on the Research laboratory on Human Reproduction's Web site
Fertility Preservation
Thanks to recent advances in oncology, the life expectancy of cancer patients has greatly increased. However, the chemotherapy and radiotherapy treatments used can be gonadotoxic and lead to infertility. Today, the long-term quality of life has become a major concern. The lab has pioneered in the development of fertility preservation techniques and restoration of ovarian function in women after treatment.
Research
Research Laboratory on Human Reproduction brings together fundamental and clinical researches with different background to work on fertility preservation and other aspect of reproduction
Last Publications
The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?
Klees C, Alexandri C, Demeestere I, Lybaert P.
Int J Mol Sci. 2023 Dec 29;25(1):460. doi: 10.3390/ijms25010460.
BRCA Mutations and Fertility Preservation.
Dias Nunes J, Demeestere I, Devos M.
Int J Mol Sci. 2023 Dec 22;25(1):204. doi: 10.3390/ijms25010204.
A Journey to Reach the Ovary Using Next-Generation Technologies.
Nguyen TTA, Demeestere I.
Int J Mol Sci. 2023 Nov 22;24(23):16593. doi: 10.3390/ijms242316593.
Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
Devos M, Dias Nunes J, Donfack Jiatsa N, Demeestere I.
Sci Rep. 2023 Sep 15;13(1):15346. doi: 10.1038/s41598-023-41954-0.
Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women.
Prokurotaite E, Condorelli M, Dechene J, Bouziotis J, Lambertini M, Demeestere I.
Life (Basel). 2023 Apr 1;13(4):930. doi: 10.3390/life13040930.
Gene Expression Analyses in Human Follicles
Melody Devos, Joana Dias Nunes, Isabelle Demeestere
J Vis Exp. 2023 Feb 17;(192). doi: 10.3791/64807.
Devos M, Diaz Vidal P, Bouziotis J, Anckaert E, Dolmans MM, Demeestere I.
Hum Reprod. 2023 Feb 1:dead013. doi: 10.1093/humrep/dead013
Impact of Anti-HER2 Therapy Alone and With Weekly Paclitaxel on the Ovarian Reserve of Young Women With HER2-Positive Breast Cancer.
Lambertini M, Ceppi M, Anderson RA, Cameron DA, Bruzzone M, Franzoi MA, Massarotti C, El-Abed S, Wang Y, Lecocq C, Nuciforo P, Rolyance R, Pusztai L, Sohn J, Latocca MM, Arecco L, Pistilli B, Ruddy KJ, Ballestrero A, Del Mastro L, Peccatori FA, Partridge AH, Saura C, Untch M, Piccart M, Di Cosimo S, de Azambuja E, Demeestere I.
J Natl Compr Canc Netw. 2023 Jan;21(1):33-41.e16. doi: 10.6004/jnccn.2022.
Impact of letrozole-associated controlled ovarian hyperstimulation on ART outcomes and endocrinological parameters.
Goldrat O, Delbaere A, Demeestere I.
Hum Reprod. 2022 Oct 31;37(11):2722-2723. doi: 10.1093/humrep/deac206.
Efficacy and safety of controlled ovarian hyperstimulation with or without letrozole for fertility preservation in breast cancer patients: A multicenter retrospective study.
Goldrat O, De Cooman M, Mailliez A, Delbaere A, D'Orazio E, Demeestere I, Decanter C.
Eur J Cancer. 2022 Oct;174:134-141. doi: 10.1016/j.ejca.2022.07.017. Epub 2022 Aug.
Impact of cancer on cryopreserved sperm quality and fertility: A cohort study.
Pening D, Constant M, Bruynbroeck M, Delbaere A, Demeestere I.
Health Sci Rep. 2022 Jul 20;5(4):e726. doi: 10.1002/hsr2.726. eCollection 2022 Jul.
Let-7a mimic transfection reduces chemotherapy-induced damage in a mouse ovarian transplantation model
Alexandri C, Van Den Steen G, Demeestere I.
Sci Rep. 2022 Jun 27;12(1):10863. doi: 10.1038/s41598-022-14926-z.
Last News
January, 18th 2024: Open Lab Day
The clinical team from the fertility clinic, Hôpital Universitaire de Bruxelles , and our collaborators were invited to visit the Research Laboratory on Human Reproduction. A great afternoon to exchange and forge links between clinic and research!
December, 2023
The lab had contributed to the Special issue IJMS Fertility Preservation and Restoration Options with Female and Male Gonadal Tissue or Cells :
The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?
Klees C, Alexandri C, Demeestere I, Lybaert P.
BRCA Mutations and Fertility Preservation.
Dias Nunes J, Demeestere I, Devos M.
A Journey to Reach the Ovary Using Next-Generation Technologies.
Nguyen TTA, Demeestere I.
November, 15th 2023
We were honored to welcome Prof Horie and Prof Takae as a member of the research group of the Ministry of Health, Labor and Welfare of Japanes government, who have been assigned the role of visiting our oncofertility facilities!
November 2023 : 15th Annual Conference of the Oncofertility Consortium
Isabelle Demeestere was honored to be part of the Conference Program Committee of the 15th Annual Conference of the Oncofertility Consortium in Pittsburgh, USA on November 5-8, 2023. 
An amazing 3-days program with excellent talks and debates and the opportunity to discuss with all colleagues and friends from US and abroad!
Research laboratory on human Reproduction
