1. Médecine
  2. Human Reproduction

Labo de recherche en reproduction humaine

1/3

Welcome

Welcome on the Research laboratory on Human Reproduction's Web site

2/3

Fertility Preservation

Thanks to recent advances in oncology, the life expectancy of cancer patients has greatly increased. However, the chemotherapy and radiotherapy treatments used can be gonadotoxic and lead to infertility. Today, the long-term quality of life has become a major concern. The lab has pioneered in the development of fertility preservation techniques and restoration of ovarian function in women after treatment.

3/3

Research

Research Laboratory on Human Reproduction brings together fundamental and clinical researches with different background to work on fertility preservation and other aspect of reproduction

Last Publications

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?
Klees C, Alexandri C, Demeestere I, Lybaert P.
Int J Mol Sci. 2023 Dec 29;25(1):460. doi: 10.3390/ijms25010460.

BRCA Mutations and Fertility Preservation.
Dias Nunes J, Demeestere I, Devos M.
Int J Mol Sci. 2023 Dec 22;25(1):204. doi: 10.3390/ijms25010204.

A Journey to Reach the Ovary Using Next-Generation Technologies.
Nguyen TTA, Demeestere I.
Int J Mol Sci. 2023 Nov 22;24(23):16593. doi: 10.3390/ijms242316593.

Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
Devos M, Dias Nunes J, Donfack Jiatsa N, Demeestere I.
Sci Rep. 2023 Sep 15;13(1):15346. doi: 10.1038/s41598-023-41954-0. 

Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women.
Prokurotaite E, Condorelli M, Dechene J, Bouziotis J, Lambertini M, Demeestere I.
Life (Basel). 2023 Apr 1;13(4):930. doi: 10.3390/life13040930.

Gene Expression Analyses in Human Follicles
Melody Devos, Joana Dias Nunes, Isabelle Demeestere
J Vis Exp. 2023 Feb 17;(192). doi: 10.3791/64807.

Impact of first chemotherapy exposure on follicle activation and survival in human cryopreserved ovarian tissue.
Devos M, Diaz Vidal P, Bouziotis J, Anckaert E, Dolmans MM, Demeestere I.
Hum Reprod. 2023 Feb 1:dead013. doi: 10.1093/humrep/dead013

Impact of Anti-HER2 Therapy Alone and With Weekly Paclitaxel on the Ovarian Reserve of Young Women With HER2-Positive Breast Cancer.
Lambertini M, Ceppi M, Anderson RA, Cameron DA, Bruzzone M, Franzoi MA, Massarotti C, El-Abed S, Wang Y, Lecocq C, Nuciforo P, Rolyance R, Pusztai L, Sohn J, Latocca MM, Arecco L, Pistilli B, Ruddy KJ, Ballestrero A, Del Mastro L, Peccatori FA, Partridge AH, Saura C, Untch M, Piccart M, Di Cosimo S, de Azambuja E, Demeestere I.
J Natl Compr Canc Netw. 2023 Jan;21(1):33-41.e16. doi: 10.6004/jnccn.2022.

Impact of letrozole-associated controlled ovarian hyperstimulation on ART outcomes and endocrinological parameters.
Goldrat O, Delbaere A, Demeestere I.
Hum Reprod. 2022 Oct 31;37(11):2722-2723. doi: 10.1093/humrep/deac206.

Efficacy and safety of controlled ovarian hyperstimulation with or without letrozole for fertility preservation in breast cancer patients: A multicenter retrospective study.
Goldrat O, De Cooman M, Mailliez A, Delbaere A, D'Orazio E, Demeestere I, Decanter C.
Eur J Cancer. 2022 Oct;174:134-141. doi: 10.1016/j.ejca.2022.07.017. Epub 2022 Aug.
 

Impact of cancer on cryopreserved sperm quality and fertility: A cohort study.
Pening D, Constant M, Bruynbroeck M, Delbaere A, Demeestere I.
Health Sci Rep. 2022 Jul 20;5(4):e726. doi: 10.1002/hsr2.726. eCollection 2022 Jul.

Let-7a mimic transfection reduces chemotherapy-induced damage in a mouse ovarian transplantation model
Alexandri C, Van Den Steen G, Demeestere I.
Sci Rep. 2022 Jun 27;12(1):10863. doi: 10.1038/s41598-022-14926-z.
 

Last News

Presentation to 52nd Meeting of BSRM


Congratulation to Caroline Gossart who presented for the first time her abstract on Reproductive outcomes after OTC. She was selected for oral presentation at the 52nd Scientific Meeting of BSRM (Belgian Society of Reproduction Medecine) in Gent.



Fonds Ithier 2024


We are deeply grateful to have received a grant from the Fonds Ithier for our project, "BRCA and Fertility," during the ceremony held at the Museum of Medicine, ULB, on December 9.