1. Médecine
  2. Human Reproduction

Labo de recherche en reproduction humaine



Welcome on the Research laboratory on Human Reproduction's Web site


Fertility Preservation

Thanks to recent advances in oncology, the life expectancy of cancer patients has greatly increased. However, the chemotherapy and radiotherapy treatments used can be gonadotoxic and lead to infertility. Today, the long-term quality of life has become a major concern. The lab has pioneered in the development of fertility preservation techniques and restoration of ovarian function in women after treatment.



Research Laboratory on Human Reproduction brings together fundamental and clinical researches with different background to work on fertility preservation and other aspect of reproduction

Last Publications

Regulation of follicular activation signaling pathways by in vitro inhibition of YAP/TAZ activity in mouse ovaries.
Devos M, Dias Nunes J, Donfack Jiatsa N, Demeestere I.
Sci Rep. 2023 Sep 15;13(1):15346. doi: 10.1038/s41598-023-41954-0. 

Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women.
Prokurotaite E, Condorelli M, Dechene J, Bouziotis J, Lambertini M, Demeestere I.
Life (Basel). 2023 Apr 1;13(4):930. doi: 10.3390/life13040930.

Gene Expression Analyses in Human Follicles
Melody Devos, Joana Dias Nunes, Isabelle Demeestere
J Vis Exp. 2023 Feb 17;(192). doi: 10.3791/64807.

Impact of first chemotherapy exposure on follicle activation and survival in human cryopreserved ovarian tissue.
Devos M, Diaz Vidal P, Bouziotis J, Anckaert E, Dolmans MM, Demeestere I.
Hum Reprod. 2023 Feb 1:dead013. doi: 10.1093/humrep/dead013

Impact of Anti-HER2 Therapy Alone and With Weekly Paclitaxel on the Ovarian Reserve of Young Women With HER2-Positive Breast Cancer.
Lambertini M, Ceppi M, Anderson RA, Cameron DA, Bruzzone M, Franzoi MA, Massarotti C, El-Abed S, Wang Y, Lecocq C, Nuciforo P, Rolyance R, Pusztai L, Sohn J, Latocca MM, Arecco L, Pistilli B, Ruddy KJ, Ballestrero A, Del Mastro L, Peccatori FA, Partridge AH, Saura C, Untch M, Piccart M, Di Cosimo S, de Azambuja E, Demeestere I.
J Natl Compr Canc Netw. 2023 Jan;21(1):33-41.e16. doi: 10.6004/jnccn.2022.

Impact of letrozole-associated controlled ovarian hyperstimulation on ART outcomes and endocrinological parameters.
Goldrat O, Delbaere A, Demeestere I.
Hum Reprod. 2022 Oct 31;37(11):2722-2723. doi: 10.1093/humrep/deac206.

Efficacy and safety of controlled ovarian hyperstimulation with or without letrozole for fertility preservation in breast cancer patients: A multicenter retrospective study.
Goldrat O, De Cooman M, Mailliez A, Delbaere A, D'Orazio E, Demeestere I, Decanter C.
Eur J Cancer. 2022 Oct;174:134-141. doi: 10.1016/j.ejca.2022.07.017. Epub 2022 Aug.

Impact of cancer on cryopreserved sperm quality and fertility: A cohort study.
Pening D, Constant M, Bruynbroeck M, Delbaere A, Demeestere I.
Health Sci Rep. 2022 Jul 20;5(4):e726. doi: 10.1002/hsr2.726. eCollection 2022 Jul.

Let-7a mimic transfection reduces chemotherapy-induced damage in a mouse ovarian transplantation model
Alexandri C, Van Den Steen G, Demeestere I.
Sci Rep. 2022 Jun 27;12(1):10863. doi: 10.1038/s41598-022-14926-z.

A Minimal Model Shows that a Positive Feedback Loop Between sNHE and SLO3 can Control Mouse Sperm Capacitation.
Bertrand de Prelle , Pascale Lybaert , David Gall
Front Cell Dev Biol. 2022 Mar 25;10:835594. doi: 10.3389/fcell.2022.835594.

Ovarian toxicity of carboplatin and paclitaxel in mouse carriers of mutation in BRIP1 tumor suppressor gene
Ntemou E, Vidal PD, Alexandri C, Van den Steen G, Lambertini M, Demeestere I.
Sci Rep. 2022 Feb 1;12(1):1658. doi: 10.1038/s41598-022-05357-x.

A retrospective study evaluating the impact of scattering radiation from imaging procedures on oocyte quality during ovarian stimulation for fertility preservation in young breast cancer patients.
Condorelli M, Sens M, Goldrat O, Delbaere A, Racapé J, Lambertini M, Demeestere I. 
Breast Cancer Res Treat. 2022 Jan 18. doi: 10.1007/s10549-021-06489-w. 

Last News

February 2023 : ESHRE Special Interest Group

Isabelle Demeestere is proud to join the team of the ESHRE Special Interest Group of fertility preservation (@SIGFertPres) as Senior Deputy!

We aim to provide the best of science and discuss hot topic in the field in the ESHRE Campus, ESHRE Course and Webseminars.

The full program is available on https://www.eshre.eu/Education/

August 2022 : PhD thesis of Melody Devos

Congratulations to Melody, she completed her PhD thesis after 5 years of hard works on signaling pathways involved in the in vitro follicular activation.

Summer 2022: Discover our last Book Chapter contributions:

              Edited By Arianna D'Angelo, Kenny A. Rodriguez-Wallberg, Daniela Nogueira