Fertility preservation and Breast cancer-clinical study

A multicenter prospective cohort study of controlled ovarian stimulation in newly diagnosed breast cancer patients: the Famhope study


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Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer (POSITIVE)

Available evidence demonstrated that pregnancy after breast cancer does not increase the risk of recurrence, even in women with a hormone receptor-positive breast cancer. However, breast cancer survivors have an increase risk of infertility related to anticancer treatment and/or age. Therefore, many women interrupted the hormonal adjuvant therapy before the recommended delay of at least 5 years to attempt pregnancy. The aim of the multicentric POSITIVE trial conducted by the IBCSG is to investigate if temporary interruption of this endocrine adjuvant therapy to attempt pregnancy, is associated with a higher risk of breast cancer recurrence. As part of the translational research consortium, we also evaluate different parameters related to fertility, ovarian reserve and pregnancy in young women included in this trial. 

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CARLOTA is a retrospective study evaluating the impact of scattering radiation from imaging procedures on oocyte quality during ovarian stimulation for fertility preservation in young breast cancer patients
Indeed, questions remain regarding the potential negative impact on oocyte quality that may occur due to exposure to scattered ionizing radiation from imaging techniques when staging assessment is conducted at the same time as ovarian stimulation.

Publication : A retrospective study evaluating the impact of scattering radiation from imaging procedures on oocyte quality during ovarian stimulation for fertility preservation in young breast cancer patients

In healthy women, fertility treatment does not increase the risk of developing breast cancer. At the time of breast cancer diagnosis and before starting anticancer treatments, several studies have shown the safety of performing ART. However, the safety of ART in breast cancer survivors following completion of anticancer treatment remains under-investigated. In general, breast cancer survivors are counselled to avoid any hormonal treatment but there are limited data available on the effect of short exposure to high oestradiol levels during ART. The largest study in this regard included 25 breast cancer survivors exposed to ART and did not show a detrimental effect of ART on patient survival. Hence, taking into account that pregnancy after breast cancer does not affect cancer prognosis, defining the safety of ART in breast cancer survivors remains a priority.

Publication : Impact of ARTs on oncological outcomes in young breast cancer survivors

The purpose of this study was to evaluate efficiency and safety of controlled ovarian stimulation (COS) associated with an aromatase inhibitor (letrozole) for fertility preservation in breast cancer patients.

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Publication: Progesterone levels in letrozole associated controlled ovarian stimulation for fertility preservation in breast cancer patients