Pharmacological protection of the ovaries during chemotherapy

Recently, the laboratory developed new project to innovate in the pharmacological ovarian protection. During several years, we investigated the controversial effect of Gonadotropin-Releasing Hormone (GnRH) analogues to prevent chemotherapy inducing ovarian damage in mice model and human.

More recently, microRNAs showed high potential as master regulators of genes transcription. They regulate transcription and post-transcription of targeted genes involved in fundamental cell functions including cell proliferation and apoptosis.

Where miRNAs are used as genes modulators to increase the sensitivity of the neoplasic cells to chemotherapy, they might also be useful to reduce toxicity in healthy cells. By studying the role of miRNAs in follicular response to toxic agents, we aim to find a way to keep follicle healthy at
the quiescent stage during chemotherapy. 

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